MG, ML, and Units: the Difference Between Semaglutide Measurements

Understanding the distinctions between mg, mL, and units can be confusing since we don't encounter them in our daily lives. Though related, these measurements actually refer to different things. Let's unravel the differences in this article.


While we make a reasonable effort to ensure the quality, accuracy, and safety of the advice in our articles, it is important to state that it is provided for general information purposes only and does not constitute medical advice. This article, including text, images, and other content, is not intended to replace a consultation with an appropriately qualified medical practitioner. Semaspace does not provide medical advice. Please, consult your healthcare provider about possible interactions, contraindications, and allergies before starting any new supplement or medication.

Now, when it comes to injections, “mg,” “mL,” and “units” are different measurements used to specify the dosage or concentration of medications. Here’s an explanation of each term:

Milligram (mg): Milligram is a unit of measurement for weight. It represents one-thousandth of a gram. In the context of injections, mg is commonly used to indicate the amount of an active ingredient in a medication. For example, if a medication is prescribed as 1 mg, it means that the injection contains 1 milligram of the active substance.

Milliliter (mL): Milliliter is a unit of measurement for volume. In the context of injections, mL is used to indicate the volume of a liquid medication. It measures the total amount of liquid contained in the syringe or vial. However, it’s important to note that the volume in milliliters does not necessarily equate to the amount of active ingredient in milligrams. The concentration of the active ingredient in the medication determines the relationship between milliliters and milligrams. 

Milliliters are the same as cubic centimeters (cc), as they represent the volume of liquid the syringe can hold. On a 100 unit syringe, you might find the following conversion: 1 milliliter (mL) = 1 cubic centimeter (cc).

Units: The units on a syringe are just another measurement for the volume of liquid medication the syringe can hold or dispense. Units on a syringe are commonly used in administration guides to simplify the mixing and dosing process for medications. Using units makes it easier for patients to understand and measure the appropriate dosage. The units are typically marked along the length of the syringe. On a 100 unit syringe, you might find the following conversion: 1 milliliter (mL) = 100 units (IU).

Understanding the Concentration (mg/mL)

Understanding mL and mg is essential for comprehending and calculating the concentration of an active ingredient indicated as mg/mL (milligrams per milliliter). This information is crucial for administering the correct dosage of the medication contained in a vial. Let’s take a 5 mg semaglutide vial as an example to illustrate this concept.

Suppose you have a 5 mg vial of semaglutide powder. When you add 2 mL of bacteriostatic water to the vial and dissolve the powder, you will have 2 mL of liquid medication in the vial.

To calculate the concentration of the liquid medication per 1 mL (mg/mL), you need to determine how much of the active ingredient (semaglutide) is present in 1 mL of the liquid solution.

Here’s how we calculate it:

  • The total amount of semaglutide in the vial is 5 mg.
  • The total volume of liquid medication after adding water is 2 mL.

To find the concentration per 1 mL (mg/mL), we divide the total amount of semaglutide (5 mg) by the total volume of liquid medication (2 mL):

Concentration per 1 mL = 5 mg/2 mL = 2.5 mg/mL

So, the concentration of semaglutide in this example is 2.5 mg/mL, which means there are 2.5 milligrams of semaglutide in every milliliter of the liquid solution.

Now, let’s imagine you have a 5 mg vial of semaglutide and you need to achieve a dose of 0.5 mg from that vial. Firstly, we need to calculate the concentration of the medication in liquid form after adding 2 mL of bacteriostatic water. Once we have the concentration, we can determine how much of the liquid medication to draw in mL to get the desired dose.

Let’s go through the steps:

Step 1: Calculate the concentration of the medication in the liquid form.

Concentration (in mg/mL) = Total amount of medication (in mg) / Total volume of liquid (in mL)

Concentration = 5 mg / 2 mL

Concentration = 2.5 mg/mL

Step 2: Determine the volume of liquid medication required to get 0.5 mg dose.

Dose (in mg) = Concentration (in mg/mL) * Volume of liquid medication (in mL)

0.5 mg = 2.5 mg/mL * Volume of liquid medication

Volume of liquid medication (in mL) = 0.5 mg / 2.5 mg/mL

Volume of liquid medication (in mL) = 0.2 mL

So, to get a dose of 0.5 mg, you need to draw 0.2 mL of the liquid medication from the vial.

Dosing Instructions

Do not worry about calculating the concentration or each dose. Our guidelines have already taken care of these calculations for you. Simply follow our instructions, and you’ll be all set!

We understand that this is a very complex subject. That’s why we have meticulously crafted detailed instructions for each bundle, spanning several pages, which outline every step you need to follow. 

Our dosing instructions include a chart that provides information on the dose (in mg) as well as the corresponding measurements on the syringe (in mL and units). Additionally, the subsequent pages of the instructions provide specific details on the volume of solution to be drawn into the syringe, stated in milliliters (mL) and units. 

Remember that the dose in milligrams (mg) may not always correspond directly to the amount of solution in milliliters (mL) that needs to be drawn into the syringe for injection. This variation arises due to the concentration of semaglutide in the solution.

Here’s a picture of how to read units and milliliters (mL) on a syringe:

It’s essential to follow the dosage instructions when administering injections. If you have any doubts or concerns about the dosage, it’s always best to consult with a healthcare provider or pharmacist for clarification.

Keep in mind

Keep in mind that our instructions pertain specifically to the vials you received from us and may not be applicable to vials from other providers. Additionally, these instructions are tailored to the specific doses provided in our bundles. Instructions found on the internet or from other providers might not be suitable as they are intended for different vials, syringes, concentrations of active ingredients per milliliter of liquid, or even other drugs.

We hope this material has shed some light on one of the most common questions we get from you.

If you have any questions or need further assistance, please don’t hesitate to contact our dedicated customer support team at

As always, we are here to support you on your wellness journey.

If you remain uncertain about mixing and administering the injections on your own, it is best to consider other providers. Numerous providers offer pre-mixed semaglutide, and some even provide assistance with injections. Feel free to choose a provider that makes you feel most at ease and comfortable.

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