How to administer SEMAGLUTIDE

Dosing and injection instructions

Semaglutide Dose Escalation Schedule

Weekly dose for weight loss
Dose escalation
Month 1
(Week 1-4)
0.25 mg
Month 2
(Week 5-8)
0.5 mg
Month 3
(Week 9-12)
1 mg
Month 4
(Week 13-16)
1.7 mg
Maintenance dose
Month 5+
(Week 17 and onward)
2.4 mg

The dosage escalation schedule is based on clinical studies and is recommended only. This schedule is not mandatory for every patient as each individual responds differently to the medication. If semaglutide is working for you on the lower dosages, you may stay on the lower dosages for as long as you want, and increase the dose whenever you need it (for example, if you have plateaued in your weight loss). It is also recommended that you do not increase the dosage if you cannot tolerate the escalation. In this case, consider delaying the dose increase or reducing the dose for a few weeks.

Semaglutide Dosing

Generic semaglutide is a white powder that comes in 2 mg and 5 mg vials. This advantage of semaglutide allows you to set any dose you want. The 2 mg vial is usually used for lower dosages, while a 5 mg vial is better for higher dosages.

Before injecting semaglutide into your body, you must mix the powder with bacteriostatic water. We are providing the instructions below. The amount of bacteriostatic water depends on the dose you want to take, as described in the following table.

Click the button below to open the dosing tables corresponding to the weeks of the bundles:​

You can also download administration guides in PDF format for the Weeks 1-6 and Weeks 1-12 bundles below:

How to Mix Semaglutide

Semaglutide comes in a powder form and needs to be mixed or “reconstituted” with bacteriostatic water before use.

Bacteriostatic water is a liquid for injections that contain 0.9% benzyl alcohol as an antimicrobial preservative.

Below are the instructions on how to mix semaglutide correctly.

Clean your hands and then gather the materials for mixing.
You will need:
  • semaglutide vial;
  • bacteriostatic water vial;
  • 100 IU/1 ml syringe with a needle;
  • alcohol pad;
  • sharps disposal container for a needle.
Prepare the materials for mixing.

Remove the protective caps from your semaglutide vial and bacteriostatic water vial. Clean the top of each vial with an alcohol pad.

Attach the needle to your syringe. Do not touch the needle with your fingers, and do not let the needle touch any other surface.

Draw up the bacteriostatic water.

Depending on your bundle, you will need either 1 ml (100 IU) or 2 ml (200 IU) of bacteriostatic water.

To draw up the water, hold the bacteriostatic water vial upside down and insert the needle into the rubber cap. Slowly pull back the plunger to the 1 ml (100 IU) mark.

Inject bacteriostatic water into the Semaglutide vial.

After the bacteriostatic water has entered the syringe to the appropriate amount, take the syringe of water and insert it into the semaglutide vial.

Slowly inject all of the water into the semaglutide vial. If you feel pressure, stop and let it level out before moving on. After the bacteriostatic water has entered the vial, pull the needle out of the vial.

If you need 2 ml (200 IU) of bacteriostatic water, repeat steps 3 and 4 inject another 1 ml (100 IU) of water into the semaglutide vial.

Gently swirl the solution.

Gently swirl the solution in a circular motion until the semaglutide powder and bacteriostatic water completely combine. Do not shake the solution.


How to Inject Semaglutide

Prepare the injection materials.

To give a semaglutide shot, you will need:

  • semaglutide vial with the solution you created after mixing (hereinafter referred to as the “semaglutide solution”);
  • 100 IU/1 ml syringe with a needle (make sure to use a new syringe and a new needle for every injection);
  • alcohol pad.

Attach the needle to your syringe. Do not touch the needle with your fingers, and do not let the needle touch any other surface.

Draw up Semaglutide.

As described in the dosing tables, the amount of semaglutide solution you need in the syringe depends on the dose you want to take. You will need either 0.2 ml, 0.25 ml, 0.33 ml, 0.4 ml, 0.5 ml, or 1 ml of solution.

To draw up the semaglutide solution, hold the vial upside down and insert the needle into the vial rubber cap. Slowly pull back the plunger to the appropriate mark, indicating the amount of the solution.

After the semaglutide solution has entered the syringe, pull the needle out of the vial.

Prepare injection site.

Semaglutide is administered subcutaneously to the abdomen, thigh, or upper arm (see here). Choose the area where you plan to give the shot. Wipe the area with an alcohol pad and let it dry for a few seconds.

Make sure to use a different injection site each week when injecting in the same body region.

Inject semaglutide.

Subcutaneous injections can be given at a 90-degree angle or a 45-degree angle. The injection can be done at a 90-degree angle if 2 inches of skin can be grasped between your thumb and index finger. If only 1 inch of skin can be grasped, inject at a 45-degree angle.

Grasp the skin with the hand not holding the syringe to create a fat fold. Holding the syringe securely with the other hand, insert the needle under the skin.

When the needle is fully inserted, slowly push down on the plunger to inject the contents of the syringe. Pull out the needle at the same angle it went in.

Safely dispose of the needle.


Important Information

Frequency of Semaglutide Injections

Administer semaglutide once a week, on the same day each week. You can give an injection at any time of the day, with or without meals.
The day of the weekly injection can be changed if necessary as long as the time between two doses is at least 48 hours.

Semaglutide Missed Dose

Don’t worry if you missed your semaglutide injection. Give yourself a shot as soon as possible within 5 days after the missed dose.

If more than 5 days have passed, it is recommended to skip the missed dose and administer the next semaglutide dose on the regularly scheduled day.

How to Store Semaglutide

Semaglutide is a thermolabile product. Once solved, it should be stored in a refrigerator to retain its properties. However, leaving semaglutide at room temperature for a while or exposure to moderate heat will not instantly make it useless.

Semaglutide keeps its purity for up to 4 weeks at room temperature. However, we highly recommend putting a vial in the refrigerator as soon as possible after you find it’s left at room temperature.


While we make a reasonable effort to ensure the quality, accuracy, and safety of the content on our website, it is important to state that it is provided for general information purposes only and does not constitute medical advice. This page, including text, images, and other content, is not intended to replace a consultation with an appropriately qualified medical practitioner. Semaspace does not provide medical advice. Please, consult your healthcare provider about possible interactions, contraindications, and allergies before starting any new supplement or medication.

Healthy Diet and Exercise

One recent study showed, that patients on semaglutide lost 10% of their body weight in 20 weeks, but regained nearly all of it after they stopped taking the drug.
In order to keep losing weight, it is crucial to develop good diet and exercise habits while taking semaglutide to maintain and manage your weight effectively after the treatment.

But don’t worry if you think you lack self-control in terms of eating. Semaglutide makes losing weight so much easier mentally and physically. It allows you to reset previous harmful eating habits and start your weight loss journey from scratch. And healthy habits developed during treatment prevent gaining weight back.

What Else Should I Know About Semaglutide?

Semaglutide is a weight-loss medicine that works by mimicking a body hormone called glucagon-like peptide-1 (GLP-1), which targets areas of the brain that regulate appetite. Semaglutide helps balance out hormones like insulin, significantly reduces blood sugar, and therefore suppresses your appetite and reduces food cravings.

When taking semaglutide, it is important to check your blood sugar often, especially before and after meals and before bedtime. This will help reduce the chance of very low blood sugar levels.

To learn more and get your semaglutide supply at the best price, visit our online store –

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Semaspace does not provide medical advice. Please, consult your healthcare provider about possible interactions, contraindications, and allergies before starting any new supplement or medication.